Real-World Evidence & Data Vendors
Real-world data providers, claims and EHR analytics, tokenization and evidence-generation platforms.
36 vendors profiled
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New York, NY
Real-world evidence analytics company whose Aetion Evidence Platform applies causal inference and rigorous epidemiologic methods to generate transparent, reproducible evidence on treatment safety, effectiveness, and value. Serves biopharma, medical device companies, and regulators including the FDA and EMA.
- Aetion Evidence Platform (AEP) software
- regulatory-grade RWE studies
- comparative effectiveness and safety analyses
- Aetion Activate for code and no-code analysts
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New York, NY
Stanford-born company automating on-demand real-world evidence generation from a federated network of health system EHR data via its GENEVA OS and generative AI application ChatRWD. Cuts observational study turnaround from months to days for clinicians and life sciences customers.
- GENEVA OS evidence automation platform
- ChatRWD generative AI interface
- federated health system data network
- rapid observational studies and publication-grade consults
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Wilmington, DE
Healthcare research organization (formerly HealthCore) and wholly owned subsidiary of Elevance Health, specializing in RWE, HEOR, safety and epidemiology, and clinical research. Its Healthcare Integrated Research Database (HIRD) contains longitudinal claims and clinical data on over 80 million commercially insured US lives.
- HIRD payer claims research database
- Carelon Real World Data closed claims offering
- safety and epidemiology studies
- HEOR and late-phase research
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Cambridge, MA
Oncology-focused real-world data and AI company maintaining one of the industry's largest independent oncology research databases combining clinical, molecular, claims, and imaging data. Provides SaaS solutions and RWE services to life sciences companies, CROs, medical societies, and regulators in the US, Europe, and Japan.
- oncology real-world datasets (clinico-genomic, claims-linked)
- eurekaHealth / CARA AI software platform
- RWE study services and external control arms
- clinical trial optimization analytics
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Waltham, MA
Operator of syndicated prospective observational registries, including nine autoimmune and inflammatory registries, spanning 400+ investigator sites and over 100,000 longitudinally followed patients in the US, Canada, and Japan. Provides regulatory-grade registry data and pharmacovigilance services to biopharma.
- syndicated disease registries (RA, psoriasis, IBD, etc.)
- post-approval safety studies
- pregnancy registries
- registry-based RWE analytics
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Waltham, MA
Statistical software and advanced analytics company providing real-world evidence and HEOR services, including RWD analytics, evidence synthesis, and regulatory-grade observational research, alongside its market-leading clinical trial design software. Supports 37 of the 40 largest pharma companies.
- RWE study design and analytics
- evidence synthesis and network meta-analysis
- HEOR and market access statistics
- statistical software (East, StatXact)
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New York, NY
Health data connectivity company whose privacy-preserving tokenization is the de facto standard for linking de-identified patient records across claims, EHR, labs, and specialty pharmacy data in the US. Commercial data ecosystems, including specialty pharmacy data aggregation, rely on its linkage infrastructure.
- patient-level tokenization and record linkage
- de-identification and privacy compliance
- data ecosystem/marketplace connectivity
- specialty pharmacy data linkage
- RWE analytics (via Aetion)
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San Mateo, CA
Health measurement company generating person-generated health data (wearable sensor data, ePROs, at-home diagnostics) from a consented network of about 5 million US participants. Designs and runs real-world studies quantifying how patients experience disease and treatment in everyday life.
- person-generated health data collection
- virtual/site-less real-world studies
- digital measures and sensor analytics
- ePRO and at-home testing programs
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New York, NY
Oncology-focused health technology company that curates EHR-derived, research-grade real-world data from a national network of community oncology practices and academic centers using its OncoEMR software. Offers end-to-end RWE solutions from data licensing to analytic and scientific services for cancer drug development.
- oncology EHR-derived real-world data
- chart abstraction and data curation
- external control arms
- RWE study design and analytics
- regulatory-grade evidence services
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Hoboken, NJ
Tech-enabled RWE and HEOR consultancy founded in 2009, supporting life sciences companies with HEOR strategy, market access and value strategy, economic modeling, and evidence synthesis from offices in Hoboken, NJ and Newcastle, UK.
- HEOR consulting
- Market access & value strategy
- Economic modeling
- Evidence synthesis
- Payer research (RPR platform)
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Philadelphia, PA
Privacy-protected health data exchange whose marketplace and HVID identity resolution platform let pharma license and link de-identified claims, pharmacy, lab, and EHR data across hundreds of millions of US patients. Its acquisition of Symphony Health from ICON added one of the largest US prescription and commercial pharmacy analytics assets.
- HealthVerity Marketplace data licensing
- identity resolution and tokenized record linkage
- prescription and pharmacy claims data (Symphony Health)
- commercial and regulatory-grade RWD delivery
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New York, NY
Data science company behind NeuroBlu, the largest NLP-enriched behavioral health and neurology real-world database, with over 46 million de-identified patient lives from longitudinal EHR data. Serves biopharma with analytics for evidence generation in psychiatry and neurodegenerative disease.
- NeuroBlu behavioral health RWD platform
- NLP extraction from psychiatric clinical notes
- cohort discovery and outcomes analytics
- RWE studies in mental health and neurology
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Bowie, MD
Healthcare data and cloud analytics company whose MORE2 Registry is one of the largest US primary-source claims datasets, spanning over 400 million unique lives and 90+ billion medical events. Its life sciences business supports commercial analytics, payer quality insights, and RWE on the Inovalon ONE Platform.
- MORE2 Registry claims dataset
- payer and Medicare Advantage analytics
- data linking for commercial and RWE use
- commercial analytics on the Inovalon ONE Platform
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Durham, NC
Global human data science company whose prescription and sales datasets (National Prescription Audit, National Sales Perspectives, LRx longitudinal prescription data, Xponent) are the industry standard for measuring US pharmaceutical demand. Its commercial analytics platform supports HCP targeting, launch tracking, and omnichannel engagement for pharma.
- National Prescription Audit (NPA)
- longitudinal prescription data (LRx)
- national sales data (NSP)
- commercial analytics and HCP targeting
- launch analytics
- specialty pharmacy data integration
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New York, NY
Healthcare data and analytics company whose Healthcare Map links de-identified claims, EHR, lab, and payer records for about 330 million US patients. Life sciences commercial teams use its MapLab and Prism applications for patient finding, HCP targeting, market sizing, and launch analytics.
- Healthcare Map patient-level dataset
- patient journey and treatment pattern analytics
- HCP and account targeting
- market sizing and launch analytics
- integrated patient insurance dataset
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New York, NY
Clinical trial technology leader whose Medidata Link solution connects patient-level clinical trial data with real-world data via tokenization-based linkage, enabling long-term outcomes follow-up and hybrid evidence generation. Part of Dassault Systemes, it also offers AI-driven synthetic control arm and analytics products.
- Medidata Link trial-to-RWD linkage
- tokenization partner integrations
- synthetic/external control arms (Medidata AI)
- clinical data platform
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Ann Arbor, MI
Health data and analytics company (formerly IBM Watson Health) whose MarketScan Research Databases are among the longest-running US commercial claims databases, widely used for payer, HEOR, and commercial analytics. Expanded its Medicare database and launched a Linked Claims + EHR Database with Veradigm.
- MarketScan commercial, Medicare and Medicaid claims databases
- linked claims + EHR data (with Veradigm)
- treatment pathway and market analytics
- HEOR analytics and research support
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Cambridge, MA
AI company that structures decades of unstructured EHR data (clinical notes, imaging, pathology, waveforms) from a federated network of premier health systems including Mayo Clinic, Duke Health, and Emory into research-ready real-world datasets. Partners with biopharma for target discovery, trial design, and evidence generation.
- nSights EMR data platform
- de-identified multimodal clinical data
- AI-driven phenotyping and biomarker discovery
- pharma research collaborations
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Boston, MA
Real-world data and AI technology company operating the OM1 Real-World Data Cloud with over 300 million patients and deep specialty registries in chronic conditions such as rheumatology, dermatology, cardiology, and behavioral health. Provides outcomes research, AI-derived phenotyping (PhenOM), and evidence generation for life sciences.
- specialty condition registries and datasets
- linked clinical and claims RWD
- AI phenotyping and predictive models
- regulatory and HEOR evidence services
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Boston, MA
McKesson's oncology insights and technology business, generating community-oncology real-world data from the iKnowMed EHR used across The US Oncology Network, covering more than 2.4 million patients and 80+ tumor types. Provides longitudinal oncology datasets, AI/NLP-curated evidence, and real-world research services to life sciences companies.
- community oncology EHR-derived RWD
- ON.Journey longitudinal oncology datasets
- real-world research studies
- provider education and point-of-care technology
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Eden Prairie, MN
The life sciences data and analytics arm of Optum (UnitedHealth Group), offering large de-identified administrative claims and linked EHR data assets plus HEOR and RWE study services. Its assets, including Clinformatics Data Mart and Market Clarity linked claims-EHR data, are widely used in peer-reviewed pharmacoepidemiology and outcomes research.
- adjudicated claims data
- linked claims + EHR data (Market Clarity)
- HEOR studies
- epidemiology and safety studies
- RWE consulting
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Austin, TX
Oracle's life sciences division develops Argus Safety (Safety One Argus), an industry-standard pharmacovigilance case management platform supporting intake, case processing, signal detection, and global regulatory reporting for drugs, biologics, vaccines, and devices. Widely used by pharma sponsors and CROs for both pre- and post-market safety surveillance.
- safety case management (Argus)
- regulatory reporting (E2B R3, eVAERS, eMDR)
- signal detection
- safety workflow automation
- MedDRA/WHO Drug coding
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Boston, MA
Healthcare analytics company whose Instant Health Data (IHD) platform lets pharma HEOR and RWE teams analyze large claims and EHR datasets without complex programming. Part of Norstella, it also offers the NorstellaLinQ linked real-world data asset and AI tools (Ella AI, LinQNotes).
- IHD real-world data analytics software
- IHD Cloud data centralization
- NorstellaLinQ linked RWD
- AI-assisted cohort building
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San Francisco, CA
Patient-centered real-world data company that collects and abstracts complete medical records with patient consent, using an LLM trained on 350M+ annotations to build deep longitudinal datasets, especially in rare disease and neurology. Runs observational studies and provides curated RWD to biopharma.
- patient-consented medical record collection and abstraction
- direct-to-patient observational studies
- PROs linked to clinical records
- PicnicAI record structuring
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New York, NY
Real-world data company specializing in clinical and genomic laboratory data, offering a managed RWD marketplace with harmonized lab and health records on more than 325 million de-identified US patients. Commercial teams use its AI-standardized lab data for patient finding and biomarker-driven HCP targeting in oncology and rare disease.
- harmonized lab results data
- Prognos Factor RWD marketplace
- AI-driven patient finding
- biomarker and diagnosis-based targeting analytics
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Wayne, PA
Healthcare analytics company operating the HealthNexus platform over one of the largest US medical and pharmacy claims databases (CLEAR Claims), serving life sciences commercial teams, agencies, providers, and payers. Supports HCP targeting, patient journey, market access, and marketing audience analytics.
- HealthNexus analytics platform
- CLEAR Claims medical/pharmacy claims data
- provider (HCP) data and targeting analytics
- SDOH-enriched datasets
- audience building for healthcare marketing
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Dallas, TX
Real-world data analytics and HEOR firm providing life sciences companies access to all-payer medical and pharmacy claims covering more than 80% of the US healthcare system. Delivers retrospective RWE studies, data advisory services, and rapid insights via its RWD Insights Direct offering.
- all-payer claims data analytics
- HEOR and outcomes research studies
- RWD Insights Direct
- publication and dossier support
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San Francisco, CA
Oncology real-world evidence company that partners with community health systems to curate longitudinal cancer patient data, offering fit-for-purpose datasets (Syapse Cohorts) and RWE services to life sciences and regulators. Acquired by N-Power Medicine in late 2024 to combine RWD with a prospective clinical research network.
- oncology real-world datasets and cohorts
- health system data curation
- regulatory-grade RWE studies
- mortality-linked oncology outcomes data
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Durham, NC
Health evidence solutions company generating real-world evidence from longitudinal patient registries and curated RWD, with deep therapeutic focus in liver disease, gastroenterology, and dermatology. Provides regulatory-grade analyses for drug development, label expansion, and post-marketing surveillance.
- disease registries (e.g., TARGET-NASH)
- data abstraction and curation
- regulatory-grade RWE analytics
- post-marketing and pharmacovigilance studies
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Chicago, IL
Precision medicine company combining genomic diagnostic testing with one of the largest multimodal clinical and molecular real-world datasets, licensed to life sciences companies for research and evidence generation. Its Lens platform provides AI-driven analytics over de-identified clinical, genomic, and imaging data.
- multimodal clinical-genomic data licensing
- Lens data analytics platform
- evidence generation and biomarker studies
- companion diagnostics development
- clinical trial matching
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Cambridge, MA
Operator of a global federated real-world data network built with more than 13,000 healthcare providers across 20+ countries, aggregating de-identified longitudinal records on over 300 million patients. Its LIVE platform supports cohort feasibility, trial design, safety monitoring, and RWE generation without data leaving member institutions.
- federated global EHR data network
- cohort discovery and trial feasibility
- protocol design analytics
- de-identified datasets for RWE studies
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Bellevue, WA
Health-system-owned data company aggregating de-identified EHR data from 30 US health systems covering more than 120 million patients, linked with closed claims for over 200 million patients. Provides daily-updated, regulatory-grade data for HEOR, safety, and comparative effectiveness research.
- de-identified EHR data including notes and images
- linked closed claims (commercial, Medicare, Medicaid)
- Truveta Studio analytics environment
- safety surveillance and HEOR research support
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Pleasanton, CA
Veeva's data business offers Compass, longitudinal anonymous patient-level data (prescriptions, procedures, diagnoses) built on the Crossix data platform representing over 300 million US health lives. Used by biopharma for patient journey, market sizing, prescriber-level projections, and privacy-safe marketing measurement.
- Compass Patient longitudinal claims data
- Compass Prescriber/National projections
- Crossix privacy-safe marketing measurement
- data licensing for commercial analytics
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Chicago, IL
Healthcare technology company (formerly Allscripts) whose ambulatory EHR network powers the Veradigm Network real-world data asset and point-of-care media/HCP engagement channels used by pharma commercial teams. Offers linked claims + EHR data with Merative for payer and life sciences analytics.
- ambulatory EHR-derived real-world data
- Veradigm Network data licensing
- point-of-care HCP engagement
- linked claims + EHR database (with Merative)
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San Francisco, CA
Digital health company that is the exclusive data curation partner for major medical society registries, including the American Academy of Ophthalmology IRIS Registry and the American Academy of Neurology Axon Registry, covering some 90 million de-identified patients. Transforms registry EHR data into disease-specific Qdata modules for RWE, trial enablement, and quality reporting.
- medical society registry data management (IRIS, Axon, urology)
- Qdata curated disease datasets
- VeraQ data engine including ophthalmic imaging
- RWE analytics and clinical trial solutions
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Menlo Park, CA
Silicon Valley real-world evidence company focused on 'high-validity' RWE, using AI to combine structured EHR data with clinical narrative text to generate evidence with measured accuracy and traceability for regulatory and reimbursement use. Offers observational research and pragmatic registry products.
- high-validity RWE studies
- Verantos Evidence Platform
- pragmatic registries
- external control arms and regulatory evidence
